Improved Modeling of Human AD with an Automated Culturing Platform for iPSC Neurons, Astrocytes and Microglia

Investigators generated a induced pluripotent stem cell Alzheimer’s disease model using human derived cells, which showed signs of Aβ plaques, dystrophic neurites around plaques, synapse loss, dendrite retraction, axon fragmentation, phospho-Tau induction, and neuronal cell death in one model.