The authors applied a combination of translating ribosome affinity purification and ribosome profiling to identify biologically relevant prion-induced changes during disease progression in a cell-type specific and genome-wide manner. Terminally diseased mice with severe neurological symptoms showed extensive alterations in astrocytes and microglia.
High‐performance secretome protein enrichment with click sugars method was used to identify the secretory response of brain slices upon LPS‐induced neuroinflammation and to establish the cell type‐resolved mouse brain secretome resource using primary astrocytes, microglia, neurons, and oligodendrocytes.
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Tüshaus, J., Müller, S. A., Kataka, E. S., Zaucha, J., Sebastian Monasor, L., Su, M., Güner, G., Jocher, G., Tahirovic, S., Frishman, D., Simons, M., & Lichtenthaler, S. F. (2020). An optimized quantitative proteomics method establishes the cell type-resolved mouse brain secretome. The EMBO Journal, n/a(n/a), e105693. https://doi.org/10.15252/embj.2020105693 Cite
Scientists studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C–C motif ligand 2, C-X-C ligand 10, and their receptors, CCR2 and CXCR3, in glioma stem cells (GSCs) and a GSC-bearing malignant glioma model.
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Shono, K., Yamaguchi, I., Mizobuchi, Y., Kagusa, H., Sumi, A., Fujihara, T., Nakajima, K., Kitazato, K. T., Matsuzaki, K., Saya, H., & Takagi, Y. (2020). Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma. Scientific Reports, 10(1), 15286. https://doi.org/10.1038/s41598-020-71857-3 Cite
Scientists found that chronic social defeat stress increased production of pro-inflammatory cytokines in lateral habenula associated with mobilization of monocytes and remodeling of extracellular matrix by increased matrix metalloproteinase activity.
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The authors developed a three-dimensional hBORG model containing major cell types important for HIV-1 neuropathogenesis; neurons and astrocytes along with incorporation of HIV-infected microglia.
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The authors describe how glial cells play a role in adult hippocampal neurogenesis in both health and disease, especially focusing on glia‐derived factors.
[European Journal of Neuroscience]
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Researchers showed that colony-stimulating factor 1 receptor (CSF1R) inhibition by PLX5622 affected the myeloid and lymphoid compartments, caused long-term changes in bone marrow-derived macrophages by suppressing interleukin 1β, CD68, and phagocytosis but not CD208, following exposure to endotoxin, and also reduced the population of resident and interstitial macrophages of peritoneum, lung, and liver but not spleen.
[Proceedings of the National Academy of Sciences of the United States of America]
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Lei, F., Cui, N., Zhou, C., Chodosh, J., Vavvas, D. G., & Paschalis, E. I. (2020). CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1922788117 Cite
Two‐photon vital microscopy demonstrated normal morphology and resting motility of microglia but strongly diminished number of microglial cells that migrated to the photolesion site in 5xFAD mice.
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Stoyanov, S., Sun, W., Düsedau, H. P., Cangalaya, C., Choi, I., Mirzapourdelavar, H., Baidoe‐Ansah, D., Kaushik, R., Neumann, J., Dunay, I. R., & Dityatev, A. (n.d.). Attenuation of the extracellular matrix restores microglial activity during the early stage of amyloidosis. Glia, n/a(n/a). https://doi.org/10.1002/glia.23894 Cite
Investigators extended the characterization of iPSC‐microglia and iPSC‐macrophages with the analysis of their transcriptome profile. These cellular models were employed to evaluate neuroimmune toxicity in vitro and to investigate the immune‐modulatory properties of interleukin 13.
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Quarta, A., Meese, T., Pieters, Z., Breedam, E. V., Blon, D. L., Broeckhoven, J. V., Hendrix, S., Goossens, H., Hens, N., Berneman, Z., Nieuwerburgh, F. V., & Ponsaerts, P. (n.d.). Murine induced pluripotent stem cell-derived neuroimmune cell culture models emphasize opposite immune-effector functions of interleukin 13-primed microglia and macrophages in terms of neuroimmune toxicity. Glia, n/a(n/a). https://doi.org/10.1002/glia.23899 Cite
Investigators showed a population of ameboid microglia migrating from the ventricular zone into the corpus callosum during early postnatal development, phagocytosing viable oligodendrocyte progenitor cells before onset of myelination.
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Researchers tested whether a gene therapy strategy to reduce Siglec-3 (CD33) on microglia in Alzheimer’s disease could decrease amyloid beta plaque load.
[Human Molecular Genetics]
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