Loss of NPC1 triggered enhanced phagocytic uptake and impaired myelin turnover in microglia that precede neuronal death.
[Nature Communications]
Colombo, A., Dinkel, L., Müller, S. A., Sebastian Monasor, L., Schifferer, M., Cantuti-Castelvetri, L., König, J., Vidatic, L., Bremova-Ertl, T., Lieberman, A. P., Hecimovic, S., Simons, M., Lichtenthaler, S. F., Strupp, M., Schneider, S. A., & Tahirovic, S. (2021). Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nature Communications, 12(1), 1158. https://doi.org/10.1038/s41467-021-21428-5 Cite
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