Tag results:
microglia
Cancer Stem Cell News
Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma
[Cancer Immunology Research] Scientists showed that circadian locomotor output cycles kaput (CLOCK) and its heterodimeric partner brain and muscle ARNT-like 1 in glioma stem cells drive immunosuppression in glioblastoma.
Neural Cell News
Microglia/Macrophage-Derived Human CCL18 Promotes Glioma Progression via CCR8-ACP5 Axis Analyzed in Humanized Slice Model
[Cell Reports] The authors studied the importance of CCL18, a cytokine expressed in human but not in rodent glioma-associated microglia/macrophages, as a modulator of glioma growth.
Neural Cell News
Life and Death of Microglia: Mechanisms Governing Microglial States and Fates
[Immunology Letters] The authors summarize the current knowledge on the possible microglial states during development, homeostasis, and perturbation.
Neural Cell News
Control of Complex Behavior by Astrocytes and Microglia
[Neuroscience and Biobehavioral Reviews] The authors summarize current knowledge on the impact of astrocyte and microglia activity on behavioral outcomes, with a specific focus on brain areas relevant to higher cognitive control, reward-seeking, and circadian regulation.
Mesenchymal Cell News
TNF-α Stimulation Enhances the Neuroprotective Effects of Gingival MSCs Derived Exosomes in Retinal Ischemia-Reperfusion Injury via the MEG3/miR-21a-5p Axis
[Biomaterials] Exosomes from the conditioned medium (CM) of gingival MSC were isolated by ultracentrifugation and were injected into the vitreous of mice. The results showed that intraocular injection of TNF-α-stimulated gingival MSC into mice with ischemia-reperfusion injury notably reduced inflammation and cell loss than that with G-exos.
Immune Regulation News
CSF-1 Maintains Pathogenic but Not Homeostatic Myeloid Cells in the Central Nervous System during Autoimmune Neuroinflammation
[Proceedings of the National Academy of Sciences of the United States of America] Investigators found that targeting colony stimulating factor 1 (CSF-1) with neutralizing antibody halted ongoing encephalomyelitis, with efficacy superior to colony CSF-1 receptor inhibitor BLZ945, whereas IL-34 neutralization had no effect, suggesting that pathogenic myeloid cells were maintained by CSF-1.