Tag Archives: astrocytes

A Modified Nucleoside 6-thio-2′-deoxyguanosine Exhibits Anti-tumor Activity in Gliomas

Four patient-derived xenografts, two patient-derived organoi and two xenografts of human glioma cell lines were used to further investigate the therapeutic efficacy of 6-thio-2′-deoxyguanosine.
[Clinical Cancer Research]
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Astrocytic YAP Prevents the Demyelination through Promoting Expression of Cholesterol Synthesis Genes in Experimental Autoimmune Encephalomyelitis

Researchers found that YAP was upregulated and activated in astrocytes of spinal cords of encephalomyelitis mice through suppression of the Hippo pathway.
[Cell Death & Disease]
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SFRP1 Modulates Astrocyte-to-Microglia Crosstalk in Acute and Chronic Neuroinflammation

The authors showed that secreted frizzled-related protein 1 (SFRP1), a multifunctional regulator of cell-to-cell communication, was part of the cellular crosstalk underlying neuroinflammation.
[EMBO Reports]
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Revisiting Astrocyte to Neuron Conversion with Lineage Tracing In Vivo

Using stringent lineage tracing in the mouse brain, investigators showed that the presumed astrocyte-converted neurons were actually endogenous neurons.
[Cell]
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Glial and Myeloid Heterogeneity in the Brain Tumor Microenvironment

The authors discuss the immune modulatory functions of microglia, monocyte-derived macrophages and astrocytes in brain metastases and glioma.
[Nature Reviews Cancer]
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Cend1 and Neurog2 Efficiently Reprogram Human Cortical Astrocytes to Neural Precursor Cells and Induced-Neurons

Scientists investigated the neuronal reprogramming capacity of CEND1 and/or Neurogenin-2 (NEUROG2) upon their overexpression on primary human adult cortical astrocytes.
[International Journal of Developmental Biology]
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Investigating Receptor-Mediated Antibody Transcytosis Using Blood–Brain Barrier Organoid Arrays

Investigators applied a novel bioengineering approach to generate human blood-brain barrier organoids by the self-assembly of astrocytes, pericytes and brain endothelial cells with unprecedented throughput and reproducibility using micro patterned hydrogels.
[Fluids and Barriers of the CNS]
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Low Temperature Plasma Irradiation Products of Sodium Lactate Solution That Induce Cell Death on U251SP Glioblastoma Cells Were Identified

Scientists quantified several major chemical products, such as pyruvate, formate, and acetate, in plasma-activated L-sodium lactate solution by nuclear magnetic resonance analysis.
[Scientific Reports]
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circFLNA Promotes Glioblastoma Proliferation and Invasion by Negatively Regulating miR-199-3p Expression

Researchers aimed to identify differentially expressed circular RNAs in glioblastoma. Reverse transcription‑quantitative PCR was used to analyze the expression levels of circFLNA.
[Molecular Medicine Reports]
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RhoA Drives Actin Compaction to Restrict Axon Regeneration and Astrocyte Reactivity after CNS Injury

An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from regenerating in the adult central nervous system. Here scientists show how the two aspects are interwoven.
[Neuron]
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NAD+ Supplementation Reduces Neuroinflammation and Cell Senescence in a Transgenic Mouse Model of Alzheimer’s Disease via cGAS–STING

Scientists reported that levels of nicotinamide adenine dinucleotide (NAD)+ were reduced and markers of inflammation increased in the brains of APP/PS1 mutant transgenic mice with beta-amyloid pathology.
[Proceedings of the National Academy of Sciences of the United States of America]
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