Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation

The authors cross-compared transcriptomic and proteomic data and selected 26 candidate genes with the same expression trends in both omics analyses.
[Stem Cell Reviews and Reports]
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SUPT4H1-Edited Stem Cell Therapy Rescues Neuronal Dysfunction in a Mouse Model for Huntington’s Disease

Transplanting SUPT4H1-edited Huntington’s disease (HD)-induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) into the YAC128 HD transgenic mouse model improved motor function compared to unedited HD iPSC-NPCs.
[NPJ Regenerative Medicine]
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Astrocytes Display Cell Autonomous and Diverse Early Reactive States in Familial Amyotrophic Lateral Sclerosis

The authors revealed that reactive transformation can occur cell autonomously in human ALS astrocytes and with a striking degree of early molecular and functional heterogeneity when comparing different disease-causing mutations.
[Brain]
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GFAP Splice Variants Fine-Tune Glioma Cell Invasion and Tumor Dynamics by Modulating Migration Persistence

The authors showed that the glial fibrillary acidic protein δ (GFAPδ) and GFAPα isoforms differentially regulated the tumor dynamics of glioma cells. Depletion of either isoform increased the migratory capacity of glioma cells.
[Scientific Reports]
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Engineered Human Blood–Brain Barrier Microfluidic Model for Vascular Permeability Analysis

The authors described an in vitro model of the human blood–brain barrier self-assembled within microfluidic devices from stem-cell-derived or primary brain endothelial cells, and primary brain pericytes and astrocytes.
[Nature Protocols]
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Effect of Duty Cycles of Tumor-Treating Fields on Glioblastoma Cells and Normal Brain Organoids

The authors evaluated the effects of tumor‑treating fields with different duty cycles on glioma spheroid cells and normal brain organoids.
[International Journal of Oncology]
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Cerebral Dopamine Neurotrophic Factor Protects and Repairs Dopamine Neurons by Novel Mechanism

Scientists focus on cerebral dopamine neurotrophic factor (CDNF), an unconventional neurotrophic protein. CDNF delivered to the brain parenchyma protects and restores dopamine neurons in animal models of Parkinson’s disease.
[Molecular Psychiatry]
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Neurocognitive and Hypokinetic Movement Disorder with Features of Parkinsonism after BCMA-Targeting CAR-T Cell Therapy

Public transcriptomic datasets confirmed B cell maturation antigen (BCMA) RNA expression in the caudate of normal human brains, suggesting that this may be an on-target effect of anti-BCMA therapy.
[Nature Medicine]
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Downregulating Expression of OPTN Elevates Neuroinflammation via AIM2 Inflammasome- and RIPK1-Activating Mechanisms in APP/PS1 Transgenic Mice

Neuroinflammation is thought to be a cause of Alzheimer’s disease (AD), which is partly caused by inadequate mitophagy. As a receptor of mitophagy, the authors revealed the regulatory roles of optineurin (OPTN) on neuroinflammation in the pathogenesis of AD.
[Journal of Neuroinflammation]
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Stress Signal ULBP4, an NKG2D Ligand, Is Upregulated in Multiple Sclerosis and Shapes CD8+ T-Cell Behaviors

Human CD8+ T lymphocytes from multiple sclerosis donors and age/sex-matched healthy controls were isolated to evaluate the functional impact of soluble ULBP4.
[Neurology-Neuroimmunology & Neuroinflammation]
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Regulation of Blood–Brain Barrier Integrity by Microbiome-Associated Methylamines and Cognition by Trimethylamine N-oxide

Scientists used an integrated in vitro/in vivo approach to show that physiologically relevant concentrations of the dietary methylamine trimethylamine N-oxide enhanced blood-brain barrier integrity and protected it from inflammatory insult, acting through the tight junction regulator annexin A1.
[Microbiome]
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