Astrocytes and Oligodendrocytes Undergo Subtype-Specific Transcriptional Changes in Alzheimer’s Disease

To improve understanding of transcriptomic heterogeneity in glia during Alzheimer’s disease (AD), the authors used single-nuclei RNA sequencing to characterize astrocytes and oligodendrocytes from apolipoprotein Ɛ2/3 human AD and age- and genotype-matched non-symptomatic brains.