Glioblastoma scRNAseq Shows Treatment-induced, Immune-dependent Rise In Mesenchymal Cancer Cells, and Structural Variants in Distal Neural Stem Cells

Scientists used single-cell RNA-sequencing to analyze new and recurrent glioblastoma, and the nearby subventricular zone. They found four glioblastoma neural lineages were present in new and recurrent glioblastoma with an enrichment of the cancer mesenchymal lineage, immune cells, and reactive astrocytes in early recurrences.