Promoter and Enhancer RNAs Regulate Chromatin Reorganization and Activation of miR-10b/HOXD Locus, and Neoplastic Transformation in Glioma

The authors demonstrated that the entire miR-10b-hosting HOXD locus was activated in glioma via the cis-acting mechanism involving 3D chromatin reorganization and CTCF-cohesin-mediated looping.