microglia

[Current Opinion in Neurobiology] Scientists review the most recent advances in modeling Alzheimer's disease in organoids and other engineered 3D cell culture systems.

[Nature Communications] Scientists performed single-cell RNA-sequencing analysis of three spinal ependymoma subtypes to dissect the microenvironmental landscape of spinal ependymomas and revealed tumor-associated macrophage subsets with distinct functional phenotypes.

[Nature Neuroscience] Using transplantation of wild-type (WT) neurons, the authors showed that amyloid beta (Aβ) entered WT grafts, and that this was accompanied by microglia infiltration.

[Denali Therapeutics, Inc.] Denali Therapeutics, Inc. announced that its strategic partner Takeda Pharmaceutical Company Limited has exercised an option to co-develop and co-commercialize DNL593, an investigational, brain-penetrant progranulin replacement therapy for the potential treatment of frontotemporal dementia-granulin.

[Nature Communications] Tamoxifen-inducible and microglia-specific depletion of polyglutamine binding protein 1 (PQBP1) in primary culture in vitro and mouse brain in vivo showed that PQBP1 was essential for sensing-tau to induce nuclear translocation of nuclear factor κB (NFκB).

[Cell Death & Disease] By exposing bEnd.3 endothelial cells and primary cortical neurons to oxygen−glucose deprivation (OGD), the impact of extracellular vesicles from OGD-preconditioned microglia on angiogenesis and neuronal apoptosis by the tube formation assay and TUNEL staining was assessed.