Tau Activates Microglia via the PQBP1-cGAS-STING Pathway to Promote Brain Inflammation

Tamoxifen-inducible and microglia-specific depletion of polyglutamine binding protein 1 (PQBP1) in primary culture in vitro and mouse brain in vivo showed that PQBP1 was essential for sensing-tau to induce nuclear translocation of nuclear factor κB (NFκB).