Scientists showed that, after both polyclonal and HIV-1-specific activation, CD8A T-cells from ART displayed reduced autophagy-dependent degradation of lysosomal contents when compared to naturally HIV-1 protected elite controllers.
[Autophagy]
Loucif, H., Dagenais-Lussier, X., Beji, C., Cassin, L., Jrade, H., Tellitchenko, R., Routy, J.-P., Olagnier, D., & Grevenynghe, J. van. (2021). Lipophagy confers a key metabolic advantage that ensures protective CD8A T-cell responses against HIV-1. Autophagy, 0(0), 1–16. https://doi.org/10.1080/15548627.2021.1874134 Cite
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