microglia

[Journal of Nanobiotechnology] Scientists constructed CD73 modified extracellular vesicles and explored the anti-inflammatory effects after spinal cord injury. CD73 engineered extracellular vesicles were derived from human umbilical cord MSCs transduced by lentiviral vectors to upregulate the expression of CD73.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists reported that levels of nicotinamide adenine dinucleotide (NAD)+ were reduced and markers of inflammation increased in the brains of APP/PS1 mutant transgenic mice with beta-amyloid pathology.

[Nature] Scientists defined ‘microglia inflamed in multiple sclerosis (MS)’ and ‘astrocytes inflamed in MS’, glial phenotypes that demonstrated neurodegenerative programming.

[Light-Science & Applications] Researchers demonstrated that cognitive and memory impairment in an Alzheimer’s disease (AD) mouse model can be ameliorated by 1070-nm light via reducing cerebral β-amyloid (Aβ) burden, the hallmark of AD. The glial cells, including microglia and astrocytes, played important roles in Aβ clearance.

[Scientific Reports] The authors investigated the role of microglial chromodomain-helicase DNA-binding protein 8 and tuberous sclerosis complex 2 in cytokine expression, phagocytosis activity, and neuro/gliogenesis from neural stem cells in vitro.

[Neural Regeneration Research] The authors provide an overview of microglia regulation of synaptic plasticity and learning and memory, and discuss the possibility of microglia manipulation as a therapeutic to ameliorate cognitive deficits associated with aging, neurocognitive disorder, and mental disorders.