Tag results:
monocytes
Dermal Cell News
BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment
[Cancer Research] Emerging evidence indicates B cell activating factor (BAFF) to be an important cytokine for anti-tumor immunity. The authors generated a BAFF-overexpressing B16.F10 melanoma cell model and found that BAFF-expressing tumors grew more slowly in vivo than control tumors.
Umbilical & Placental Cell News
Toxoplasma gondii GRA28 Is Required for Placenta-Specific Induction of the Regulatory Chemokine CCL22 in Human and Mouse
[mBio] Investigators hypothesized that CCL22 induction was driven by a specific Toxoplasma gondii-secreted effector.
Human Immunology News
Monocytes Secrete CXCL7 to Promote Breast Cancer Progression
[Cell Death & Disease] To identify key immune players in the tumor microenvironment, investigators applied highly invasive MDA-MB-231 breast cancer cell lines to co-culture with human monocyte THP-1 cells and identified CXCL7 by cytokine array as one of the increasingly secreted cytokines by THP-1 cells.
Hepatic Cell News
COMMD10 Is Critical for Kupffer Cell Survival and Controls Ly6Chi Monocyte Differentiation and Inflammation in the Injured Liver
[Cell Reports] Copper metabolism MURR1 domain (COMMD10) deficiency in Kupffer cells and in other tissue-resident macrophages impedes their homeostatic survival, leading to their continuous replacement by Ly6Chi monocytes.
Mesenchymal Cell News
Cancer-Associated MSC Drive Tumor Immune Exclusion and Resistance to Immunotherapy, Which Can Be Overcome by Hedgehog Inhibition
[Science Advances] Using an immune “hot” mouse ovarian cancer model, scientists found that cancer-associated-MSCs drove CD8+ T cell tumor immune exclusion and reduced response to anti–PD-L1 immune checkpoint inhibitor via secretion of numerous chemokines.
Dermal Cell News
Oncostatin M Can Sensitize Sensory Neurons in Inflammatory Pruritus
[Science Translational Medicine] Researchers found that the cytokine oncostatin M was highly up-regulated in psoriasis, atopic dermatitis, and cutaneous T cell lymphoma, diseases associated with chronic itch.