monocytes

[Journal of Experimental Medicine] Investigators showed that monocytes acquired macrophage markers upon glomerulonephritis and may have been derived from CCR2+CX3CR1+ double-positive monocytes, which were preferentially recruited, dwelled within glomerular capillaries, and acquired proinflammatory characteristics in the nephritic kidney.

[Science] Researchers demonstrated mux-seq as a systematic approach to characterize cellular composition, identify transcriptional signatures, and annotate genetic variants associated with systemic lupus erythematosus.

[PLoS Pathogens] The authors investigated the impact of monocytes, NK cells, and CD8+ T cells in primary HTLV-1 infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type or to the HTLV-1p12KO mutant.

[Heliyon] Investigators identified and ranked clinical and immunological features associated with progression to severe COVID-19 in order to investigate an immunological signature of severe disease.

[Journal of Experimental Medicine] Researchers explored the role of miRNAs in the pathogenesis of inflammatory bowel disease (IBD) and identified reduced expression of miR-374a-5p in IBD monocytes that correlated with a module of up-regulated genes related to the inflammatory response.

[Scientific Reports] Investigators characterized monocyte subsets in controls and disease phenotypes of coronary artery disease and mmyocardial infarction patients using flow cytometry and miRNA and mRNA expression profiling using RNA sequencing.