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monocytes

Bone Marrow-Independent Adventitial Macrophage Progenitor Cells Contribute to Angiogenesis

[Cell Death & Disease] Macrophage-derived VEGF activated CD34+ progenitor cells within the adventitial vasculogenic zone to differentiate into CD31+ endothelial cells.

Mild SARS-CoV-2 Infection in Rhesus Macaques Is Associated with Viral Control Prior to Antigen-Specific T Cell Responses in Tissues

[Science Immunology] The authors used rhesus macaques to model protective primary immune responses in tissues during mild COVID-19.

Bordetella pertussis-Infected Innate Immune Cells Drive the Anti-pertussis Response of Human Airway Epithelium

[Scientific Reports] Researchers investigated the epithelial cell response to B. pertussis infection in primary human airway epithelium differentiated at air–liquid interface.

S1P Analogues SEW2871, BAF312 and FTY720 Affect Human Th17 and Treg Generation Ex Vivo

[International Immunopharmacology] The authors investigated the effects of S1P receptor 1 (S1P1) specific S1P analogue SEW2871, S1P1 and S1P5 specific BAF312, and non-selective FTY720 on human Th17 and Treg differentiation and IL-23-mediated signaling.

Necroptosis Triggers Spatially Restricted Neutrophil-Mediated Vascular Damage during Lung Ischemia Reperfusion Injury

[Proceedings of the National Academy of Sciences of the United States of America] Researchers found that TLR4 signaling in vascular endothelial cells and downstream NADPH oxidase 4 expression mediate the arrest of neutrophils, a step upstream of their extravasation.

Interferon-γ Promotes Monocyte-Mediated Lung Injury during Influenza Infection

[Cell Reports] The authors identified an interferon-γ-regulated subset of monocytes, CCR2+ monocytes, as a driver of lung damage during influenza A virus infection.

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