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myeloid cells

Pelargonic Acid Vanillylamide and Rosuvastatin Protect against Oxidized Low-Density Lipoprotein-Induced Endothelial Dysfunction by Inhibiting the NF-κB/NLRP3 Pathway and Improving Cell-Cell Junctions

[Chemico-Biological Interactions] Researchers investigated the synergistic effects of pelargonic acid vanillylamide and rosuvastatin on ox-LDL-induced inflammatory responses in human vascular endothelial cells.

The Protective Effects of Benzbromarone Against Propofol-Induced Inflammation and Injury in Human Brain Microvascular Endothelial Cells (HBMVECs)

[Neurotoxicity Research] Researchers investigated the protective property of Benzbromarone against propofol-induced injury on HBMVECs and the underlying mechanism.

De Novo Generation of Macrophage from Placenta-Derived Hemogenic Endothelium

[Developmental Cell] Researchers uncovered and experimentally validated that a CD44+ subpopulation of placental endothelial cells exhibited hemogenic potential.

Acetaldehyde Exposure Underlies Functional Defects in Monocytes Induced by Excessive Alcohol Consumption

[Scientific Reports] Blood and fecal samples were collected on admission and 4 weeks after alcohol cessation and were sequentially analyzed. Wild-type and ALDH2*2 transgenic mice were used to examine the effect of acetaldehyde exposure on liver immune responses.

Monocyte-Driven Atypical Cytokine Storm and Aberrant Neutrophil Activation as Key Mediators of COVID-19 Disease Severity

[Nature Communications] To elucidate the immunopathology underlying COVID-19 severity, researchers perform cytokine and multiplex immune profiling in COVID-19 patients.

Matrix Lumican Endocytosed by Immune Cells Controls Receptor Ligand Trafficking to Promote TLR4 and Restrict TLR9 in Sepsis

[Proceedings of the National Academy of Sciences of the United States of America] Researchers demonstrate that lumican, an ECM protein normally associated with collagens, was elevated in sepsis patients’ blood, while lumican-null mice resolved polymicrobial sepsis poorly, with reduced bacterial clearance and greater body weight loss.

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