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myeloid cells

Xenogeneic Skin Transplantation Promotes Angiogenesis and Tissue Regeneration through Activated Trem2+ Macrophages

[Science Advances] Investigators showed that collagen deposition in response to the implantation of human split-thickness skin grafts containing live cells recapitulated normal skin architecture, whereas human acellular dermal matrix grafts led to a fibrotic collagen deposition.

Targeting SYK of Monocyte-Derived Macrophages Regulates Liver Fibrosis via Crosstalking with Erk/Hif1α and Remodeling Liver Inflammatory Environment

[Cell Death & Disease] Scientists found that inhibition of monocyte-derived macrophages (MoMFs) SYK impaired the expression of CXCL1, reduced the recruitment of inflammatory cells, and promoted the phenotype cross-dress process of pro-resolution MoMFs, thereby remodeling the chronic inflammatory environment of the fibrotic liver.

Harnessing Cerebral Organoids for Alzheimer’s Disease Research

[Current Opinion in Neurobiology] Scientists review the most recent advances in modeling Alzheimer's disease in organoids and other engineered 3D cell culture systems.

LncRNA HSPA7 in Human Atherosclerotic Plaques Sponges miR-223 and Promotes the Proinflammatory Vascular Smooth Muscle Cell Transition

[Experimental & Molecular Medicine] Researchers identified and functionally validated a long noncoding RNAs using human atherosclerotic plaques. Human aortic samples were obtained from patients who underwent aortic surgery, and tissues were classified according to atherosclerotic plaques.

The Role of Immune Cells in Pulmonary Hypertension: Focusing on Macrophages

[Human Immunology] The authors reviewed the molecular mechanisms and the role of immune cells and responses involved in pulmonary hypertension development.

Impact of Donor-Derived CD34+ Infused Cell Dose on Outcomes of Patients Undergoing Allo-HCT Following Reduced Intensity Regimen for Myelofibrosis: A Study from the Chronic...

[Bone Marrow Transplantation] Investigators retrospectively analyzed 657 patients with primary or secondary myelofibrosis transplanted with use of peripheral blood stem cells after fludarabine/melphalan or fludarabine/busulfan RIC regimen.

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