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myeloid cells

Innate Immune Responses at the Asymptomatic Stage of Influenza a Viral Infections of Streptococcus pneumoniae Colonized and Non-Colonized Mice

[Scientific Reports] Researchers compared innate immune responses in the lungs of healthy colonized and non-colonized mice after Influenza A virus challenge at the initial asymptomatic stage of infection.

The Epithelial-Stromal Microenvironment in Early Colonic Neoplasia

[Molecular Cancer Research] Scientists analyzed molecular changes within the epithelial and stromal compartments of dysplastic aberrant crypt foci formed in the ascending colon, where rapidly developing interval cancers occur.

PD-L1 (Programmed Death Ligand 1) Regulates T Cell Differentiation to Control Adaptive Venous Remodeling

[Arteriosclerosis Thrombosis and Vascular Biology] In the mouse aortocaval fistula model, anti-PD-L1 antibody was given to inhibit PD-L1 activity during arteriovenous fistulae maturation.

Human Prostate Cancer Bone Metastases Have an Actionable Immunosuppressive Microenvironment

[Cancer Cell] The authors defined distinct features of the bone marrow (BM) microenvironment and analyzed single cells from bone metastatic prostate tumors, involved BM, uninvolved BM, and BM from cancer-free, orthopedic patients, and healthy individuals.

Single-Cell Analyses Reveal Key Immune Cell Subsets Associated with Response to PD-L1 Blockade in Triple-Negative Breast Cancer

[Cancer Cell] Investigators demonstrated that high levels of baseline CXCL13+ T cells are linked to the proinflammatory features of macrophages and can predict effective responses to the combination therapy.

Mycobacterium tuberculosis Exploits Focal Adhesion Kinase to Induce Necrotic Cell Death and Inhibit Reactive Oxygen Species Production

[Frontiers in Imm] The authors demonstrated that Mycobacterium tuberculosis infection triggered a time-dependent reduction in the expression of focal adhesion kinase in human macrophages.

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