myeloid cells

[Proceedings of the National Academy of Sciences of the United States of America] Microglial ramification, motility, and cytokine release are regulated by tonically active THIK-1 K+ channels on the microglial plasma membrane. Researchers examined whether these channels played a role in phagocytosis.

[Nature Communications] Researchers demonstrated that single-cell sequencing of melanoma-infiltrating immune cells showed that adenylate cyclase inhibitor micelles reduced the number of anti-inflammatory myeloid cells and checkpoint receptor expression on T cells.

[Life Sciences] In order to clarify the role of endocannabinoid system receptors in wound healing, excisional wounds were created on wildtype and CB1 and CB2 knockout mice.

[Scientific Reports] An eight-color antibody panel was used to identify seven monocyte and two dendritic cell subsets. In the learning cohort, immunophenotyping was applied to control subjects, postoperative heart surgery patients, as a model of noninfectious inflammatory responses, and blood culture-positive patients.

[Immunity] Scientists showed that uncoupling protein-2-mediated mitochondrial reprogramming and the transcription factor GATA3 specifically controlled the differentiation of pro-resolving alternatively activated macrophages in response to the alarmin IL-33.

[Blood Advances] The authors adopted CIBERSORTx to estimate the relative fractions of 22 subtypes of immune cells in the bone marrow of 316 myelodysplastic syndrome patients and correlated the results with clinical outcomes.