Effect of Simulated Microgravity Conditions of Hindlimb Unloading on Mice Hematopoietic and Mesenchymal Stromal Cells

C57BL/6 mice were randomly divided into two groups: a control group and a hindlimb suspension group. After four weeks of hindlimb suspension, scientists found that this simulated microgravity condition increased the percentage of monocytes and macrophages and decreased the percentage of B lymphocytes and mature red cells in bone marrow.
[Cell Biology International]
Dai, S., Kong, F., Liu, C., Xiao, F., Dong, X., Zhang, Y., & Wang, H. (n.d.). Effect of Simulated Microgravity Conditions of Hindlimb Unloading on Mice Hematopoietic and Mesenchymal Stromal Cells. Cell Biology International, n/a(n/a). https://doi.org/10.1002/cbin.11432 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Extracellular Cold-Inducible RNA-Binding Protein Regulates Neutrophil Extracellular Trap Formation and Tissue Damage in Acute Pancreatitis

Scientists studied the role of extracellular cold-inducible RNA-binding protein, a novel damage-associated-molecular-pattern molecule, in severe acute pancreatitis.
[Laboratory Investigation]

Sorry, but the selected Zotpress account can't be found.

Abstract
Bookmark

No account yet? Register

0
Share

Evidence of Macrophage Modulation in the Mouse Pubic Symphysis Remodeling during the End of First Pregnancy and Postpartum

Investigators used morphological and high-sensitivity molecular techniques to identify both macrophage association with ECM remodeling and the immunological processes involved in pubic symphysis changes from inflammatory mediators D18 to 3dpp.
[Scientific Reports]

Sorry, but the selected Zotpress account can't be found.

Full Article
Bookmark

No account yet? Register

0
Share

Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non-Small-Cell Lung Carcinoma

Scientists investigated tumor-associated macrophage (TAM) subtype density and distribution between tumor center and invasive margin in human lung cancer and TAM associations with overall survival.
[Cancer Research]
Zheng, X., Weigert, A., Reu, S., Guenther, S., Mansouri, S., Bassaly, B., Gattenlöhner, S., Grimminger, F., Pullamsetti, S. S., Seeger, W., Winter, H., & Savai, R. (2020). Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non-Small-Cell Lung Carcinoma. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0069 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Tumor-Initiating Cells Establish an IL-33–TGF-β Niche Signaling Loop to Promote Cancer Progression

The authors showed, using a mouse model of squamous cell carcinoma, that tumor-initiating cells play a crucial role in creating a niche microenvironment that is required for tumor progression and drug resistance.
[Science]
Taniguchi, S., Elhance, A., Duzer, A. V., Kumar, S., Leitenberger, J. J., & Oshimori, N. (2020). Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression. Science, 369(6501). https://doi.org/10.1126/science.aay1813 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Allogeneic Adipose‐Derived Stem Cells Promote Ischemic Muscle Repair by Inducing M2 Macrophage Polarization via the HIF ‐1α/IL ‐10 Pathway

The transplantation of adipose‐derived mesenchymal stem cells (ASCs) into ischemic limbs induced increased blood flow reperfusion and limb salvage rate, whereas the depletion of tissue macrophages or transplanting HIF‐1α‐silenced ASCs inhibited the therapeutic effect.
[Stem Cells]
Liu, J., Qiu, P., Qin, J., Wu, X., Wang, X., Yang, X., Li, B., Zhang, W., Ye, K., Peng, Z., & Lu, X. (n.d.). Allogeneic adipose-derived stem cells promote ischemic muscle repair by inducing M2 macrophage polarization via the HIF-1α/IL-10 pathway. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3250 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Intra-Articular Xenogeneic Mesenchymal Stem Cell-Based Therapy Increases CD4+CD25+ Cells in Synovial Fluid

The authors aimed to identify the lymphocytic response to a xenogeneic human umbilical cord-derived mesenchymal stem cell-based cell therapy.
[Veterinary Immunology and Immunopathology]
Lamers, K., Baquero, M., Karrow, N., & Hurtig, M. (2020). Intra-articular xenogeneic mesenchymal stem cell-based therapy increases CD4+CD25+ cells in synovial fluid. Veterinary Immunology and Immunopathology, 227, 110085. https://doi.org/10.1016/j.vetimm.2020.110085 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Xenogeneic Mesenchymal Stem Cell Transplantation for Mandibular Defect Regeneration

To examine donor cell survival and host immune reaction, pig bone marrow‐derived mesenchymal stem cells were labeled with CM‐DiI, loaded onto gelatin sponge, and transplanted into 5‐mm mandibular defects of immunocompetent and T cell‐deficient athymic rats.
[Xenotransplantation]
Tee, B. C., & Sun, Z. (n.d.). Xenogeneic mesenchymal stem cell transplantation for mandibular defect regeneration. Xenotransplantation, n/a(n/a), e12625. https://doi.org/10.1111/xen.12625 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo

Scientists showed that exosomes produced by naive bone marrow-derived macrophages (BMDM) contained anti-inflammatory microRNA-99a/146b/378a that were further increased in exosomes produced by BMDM polarized with IL-4.
[Cell Reports]
Bouchareychas, L., Duong, P., Covarrubias, S., Alsop, E., Phu, T. A., Chung, A., Gomes, M., Wong, D., Meechoovet, B., Capili, A., Yamamoto, R., Nakauchi, H., McManus, M. T., Carpenter, S., Van Keuren-Jensen, K., & Raffai, R. L. (2020). Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo. Cell Reports, 32(2), 107881. https://doi.org/10.1016/j.celrep.2020.107881 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Myocardial Infarction Accelerates Breast Cancer via Innate Immune Reprogramming

Scientists showed that myocardial infarction accelerates breast cancer outgrowth and cancer-specific mortality in mice and humans.
[Nature Medicine]
Koelwyn, G. J., Newman, A. A. C., Afonso, M. S., van Solingen, C., Corr, E. M., Brown, E. J., Albers, K. B., Yamaguchi, N., Narke, D., Schlegel, M., Sharma, M., Shanley, L. C., Barrett, T. J., Rahman, K., Mezzano, V., Fisher, E. A., Park, D. S., Newman, J. D., Quail, D. F., … Moore, K. J. (2020). Myocardial infarction accelerates breast cancer via innate immune reprogramming. Nature Medicine, 1–7. https://doi.org/10.1038/s41591-020-0964-7 Cite
Abstract
Bookmark

No account yet? Register

0
Share

The Commensal Skin Microbiota Triggers Type I IFN–Dependent Innate Repair Responses in Injured Skin

The authors uncovered a fundamental role of commensal skin microbiota and showed that it was mediated by the recruitment and the activation of type I interferon (IFN)-producing plasmacytoid DC.
[Nature Immunology]
Di Domizio, J., Belkhodja, C., Chenuet, P., Fries, A., Murray, T., Mondéjar, P. M., Demaria, O., Conrad, C., Homey, B., Werner, S., Speiser, D. E., Ryffel, B., & Gilliet, M. (2020). The commensal skin microbiota triggers type I IFN–dependent innate repair responses in injured skin. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-020-0721-6 Cite
Abstract
Bookmark

No account yet? Register

0
Share
Share