myeloid cells

[Scientific Reports] Researchers separated chicken bone marrow-derived mesenchymal stem cells (BM-MSCs); investigated whether BM-MSCs could improve lipopolysaccharide-induced lung and distal organ injury; and explored the underlying mechanisms.

[Cell Metabolism] Mechanistically, the authors found that grancalcin binds to the plexin-b2 receptor and partially inactivated its downstream signaling pathways, thus repressing osteogenesis and promoting adipogenesis of bone marrow mesenchymal stromal cells.

[Circulation Research] Using LysMCre-mediated mammalian STE20-like protein kinase 1/2 (Mst1/2)-deficient mice, researchers found that MST1 deficiency exacerbated cardiac dysfunction after myocardial infarction.

[Scientific Reports] Plasma markers of neutrophil extracellular traps formation were elevated in liver cirrhosis and correlated to the degree of liver dysfunction in patients with liver cirrhosis and/or hepatocellular carcinoma.

[Proceedings of the National Academy of Sciences of the United States of America] Olfr78 functioned together with Gpr132 to mediate lactate-induced generation of protumoral M2-tumor-associated macrophages. Syngeneic Olfr78-deficient mice exhibited reduced tumor progression and metastasis together with an increased anti- versus protumoral immune cell population.

[JCI Insight] Scientists demonstrated that collagen-induced DDR1 activation in cancer cells was a major stimulus for CXCL5 production, resulting in the recruitment of tumor-associated neutrophils, the formation of neutrophil extracellular traps, and subsequent cancer cell invasion and metastasis.