Cardiomyocyte IL-1R2 Protects Heart from Ischemia/Reperfusion Injury by Attenuating IL-17RA-Mediated Cardiomyocyte Apoptosis

After myocardial ischemia reperfusion surgery, IL-1R2 expression was significantly increased in heart of wild-type mice.
[Cell Death & Disease]
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LncRNA ROR Modulates Myocardial Ischemia-Reperfusion Injury Mediated by the miR-185-5p/CDK6 Axis

Researchers revealed that hypoxia/reoxygenation (H/R) treated human cardiac myocytes showed a significantly decreased miR-185-5p expression and increased expression of CDK6 and ROR.
[Laboratory Investigation]
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CXCR4 Blockade Reduces the Severity of Murine Heart Allograft Rejection by Plasmacytoid Dendritic Cell-Mediated Immune Regulation

Scientists performed fully-mismatched heart transplantations and found combination treatment to result in prolonged allograft survival.
[Scientific Reports]
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The Cardiomyocyte Disrupts Pyrimidine Biosynthesis in Non-Myocytes to Regulate Heart Repair

Scientists showed that rescue of pyrimidine biosynthesis by administration of uridine or by genetic targeting of ENPP1/AMP pathway enhanced repair after cardiac injury.
[Journal of Clinical Investigation]
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ATP-Sensitive Potassium Channels in Zebrafish Cardiac and Vascular Smooth Muscle

Using a comprehensive combination of genetically modified fish, electrophysiology, and gene expression analysis, scientists demonstrated that zebra fish cardiac myocytes and vascular smooth muscle expressed functional ATP-sensitive potassium channels channels of similar subunit composition, structure, and metabolic sensitivity to their mammalian counterparts.
[Journal of Physiology]
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MicroRNA-190b Expression Predicts a Good Prognosis and Attenuates the Malignant Progression of Pancreatic Cancer by Targeting MEF2C and TCF4

Scientists examined the expression of miR‑190b in pancreatic cancer cell lines and tissues and evaluated its effects on cancer progression.
[Oncology Reports]
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Desmoglein 2 Regulates Cardiogenesis by Restricting Hematopoiesis in the Developing Murine Heart

Researchers proposed that cardiomyocyte-driven paracrine signaling, which likely involves Notch1, directs subsequent trans-differentiation of endo- and epicardial cells.
[Scientific Reports]
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Negative Inotropic Mechanisms of β-Cardiotoxin in Cardiomyocytes by Depression of Myofilament ATPase Activity without Activation of the Classical β-Adrenergic Pathway

The effects of beta-cardiotoxin on isolated cardiac myocyte functions, calcium homeostasis, the phosphorylation level of targeted proteins, and the myofibrillar ATPase activity were studied.
[Scientific Reports]
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Distributed Synthesis of Sarcolemmal and Sarcoplasmic Reticulum Membrane Proteins in Cardiac Myocytes

Researchers identified that the molecular machinery for membrane protein synthesis occurs throughout the cardiac myocyte, and enabled distributed synthesis of membrane proteins within sub-cellular niches where the synthesized protein functions using local mRNA pools trafficked, in part, by microtubules.
[Basic Research in Cardiology]
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Control of Satellite Cell Function in Muscle Regeneration and Its Disruption in Aging

Skeletal muscle contains a designated population of adult stem cells, called satellite cells, which are generally quiescent. The authors discuss the role and regulation of satellite cells in skeletal muscle homeostasis and regeneration.
[Nature Reviews Molecular Cell Biology]
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Collagen-Derived Dipeptide Pro-Hyp Administration Accelerates Muscle Regenerative Healing Accompanied by Less Scarring after Wounding on the Abdominal Wall in Mice

Pro-Hyp administration induced many myogenically differentiated cells, including myogenin-positive myoblasts and myoglobin-positive myocytes, to migrate in the granulation tissue, while scar tissue decreased, indicating that Pro-Hyp administration accelerated muscle regenerative healing accompanied by less scarring after wounding on the abdominal wall.
[Scientific Reports]
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