A Small Molecular Compound CC1007 Induces Cross-Lineage Differentiation by Inhibiting HDAC7 Expression and HDAC7/MEF2C Interaction in BCR-ABL Pre-B-ALL

The authors investigated the anticancer effects of CC1007 in breakpoint cluster region-Abelson 1 fusion gene-negative (BCR-ABL1) pre-B-ALL cell lines and primary patient-derived BCR-ABL1 pre-B-ALL cells.
[Cell Death & Disease]
Wang, Z., Zhang, Y., Zhu, S., Peng, H., Chen, Y., Cheng, Z., Liu, S., Luo, Y., Li, R., Deng, M., Xu, Y., Hu, G., Chen, L., & Zhang, G. (2020). A small molecular compound CC1007 induces cross-lineage differentiation by inhibiting HDAC7 expression and HDAC7/MEF2C interaction in BCR-ABL1 − pre-B-ALL. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02949-1 Cite
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Prioritizing Candidates of Post-Myocardial Infarction Heart Failure Using Plasma Proteomics and Single-Cell Transcriptomics

Scientists cross-referenced differentially-expressed proteins with their differentially-expressed genes from single-cell transcriptomes of non-myocyte cardiac cells isolated from a murine myocardial infarction model.
[Circulation]
Prioritizing Candidates of Post-Myocardial Infarction Heart Failure Using Plasma Proteomics and Single-Cell Transcriptomics | Circulation. (n.d.). Retrieved September 9, 2020, from https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.045158 Cite
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Maintenance of Sarcomeric Integrity in Adult Muscle Cells Crucially Depends on Z-Disc Anchored Titin

The authors demonstrated that loss of Z-disc-anchored TTN recapitulates muscle remodeling in critical illness ‘myosinopathy’ patients, characterized by TTN-depletion and loss of thick filaments.
[Nature Communications]
Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin | Nature Communications. (n.d.). Retrieved September 9, 2020, from https://www.nature.com/articles/s41467-020-18131-2 Cite
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Atrogin1-Induced Loss of Aquaporin 4 in Myocytes Leads to Skeletal Muscle Atrophy

Scientists investigated a novel mechanism underlying skeletal muscle atrophy, they examined AQP4 expression and its regulation in muscle using the rotator cuff tear model.
[Scientific Reports]
Chung, S. W., Kim, J.-Y., Yoon, J. P., Suh, D. W., Yeo, W. J., & Lee, Y.-S. (2020). Atrogin1-induced loss of aquaporin 4 in myocytes leads to skeletal muscle atrophy. Scientific Reports, 10(1), 14189. https://doi.org/10.1038/s41598-020-71167-8 Cite
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Attenuation of Oxidative Injury with Targeted Expression of NOX2 shRNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium: A Novel Gene Therapy Approach to Atrial Fibrillation

Using a highly novel gene therapy approach in a canine, rapid atrial pacing model of atrial fibrillation, researchers demonstrated that NADPH oxidase 2 generated oxidative injury.
[Circulation]
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