Natural Killer Cells

[Journal of the American Chemical Society] The binding of anti-Globo H antibody to breast cancer cells was influenced by anti-SSEA4 antibody, and a combination of both antibodies induced a similar effect as did anti-SSEA4 antibodies alone in a reporter-based antibody-dependent cellular cytotoxicity assay, indicating that SSEA4 was a major target in breast cancer due to its higher expression than Globo H.

[Advanced Science] Transcriptomic analysis showed that IFN-γ and IFN-α signaling was downregulated in IRF8-deficient HSCs, while their response to proinflammatory cytokines was unchanged ex vivo.

[Scientific Reports] Scientists investigated the cellular response of different antigen presenting cells to the prototypical immunogenic heat shock protein, gp96, in the context of Th1 immunity.

[PLOS Biology] Scientists demonstrated that natural killer cells were protected from perforin-mediated autolysis by densely packed and highly ordered presynaptic lipid membranes, which increased packing upon synapse formation.

[Cell Research] Investigators developed a next-generation IL-15 that is activated inside the tumor microenvironment.

[Nature Communications] The authors utilized an engineered microbial organism with a six-letter semi-synthetic DNA code to generate a library of site-specific, click chemistry compatible amino acid substitutions in the human cytokine IL-2.