neural cells

[Acta Pharmacologica Sinica] Scientists demonstrated that GPR84 was highly upregulated in inflamed colon tissues of active ulcerative colitis patients and dextran sulfate sodium-induced colitis mice.

[Nature Communications] Investigators established a midbrain organoid culture system to study the developmental trajectory from pluripotent stem cells to mature dopamine neurons.

[Molecular Psychiatry] Scientists focus on cerebral dopamine neurotrophic factor (CDNF), an unconventional neurotrophic protein. CDNF delivered to the brain parenchyma protects and restores dopamine neurons in animal models of Parkinson’s disease.

[Communications Biology] Using ELISA-based chemical screening with wild and mutant superoxide dismutase (SOD1) proteins, the authors screened a new small molecule, PRG-A01, which could block the misfolding/aggregation of SOD1 or TDP-43. The drug rescued the cell death induced by mutant SOD1 in human neuroblastoma cell line.

[Experimental Neurology] A Bergmann glia population was analyzed in the adult cerebellum of different species and showed conservation of neural stem cell-associated marker expression including Sox1, Sox2 and Sox9, in chick, primate and mouse cerebellum tissue.

[Cancer Research] To investigate recurrently dysregulated genes in glioblastoma, scientists interrogated allele-specific expression, the difference in expression between two alleles of a gene, in glioblastoma stem cells derived from 43 patients.