neural cells

[Cell] Using activity-dependent cell labeling in mice, the authors captured neuronal ensembles in the InsCtx that were active under two different inflammatory conditions

[Scientific Reports] Investigators generated cerebral organoids derived from human iPSCs (hiPSCs) possessing the KCNJ11 mutation p.Val59Met (V59M) and from non-pathogenic/normal hiPSCs.

[Nature Communications] The authors identified kenpaullone (KP), which enhanced Kcc2/KCC2 expression and function in cultured rodent and human neurons by inhibiting GSK3ß. KP effectively reduced pathologic pain-like behavior in mouse models of nerve injury and bone cancer.

[Translational Psychiatry] Investigators used a human induced pluripotent stem cell (iPSC)-derived astrocyte model and investigated the temporal patterns of astroglia differentiation during developmental stages critical for schizophrenia using RNA sequencing.

[Translational Psychiatry] The authors tested the chronic effects of low and high doses of lithium on human hippocampal progenitor cells and used immunocytochemistry to investigate the effects of lithium on cell parameters implicated in neurogenesis.

[Biotechnology and Bioengineering] Investigators created a 3D model of vascularized spheroid cells using an injection-molded microfluidic chip. Gene expression analysis and immunostaining revealed that the vascular network greatly enhanced spheroid differentiation and reduced apoptosis.