The authors investigated the role of V1G1 in glioma stem cell small extracellular vesicles and their effects on primary brain cultures.
[Molecular Cancer Research]
1254621 ZLJ8M46F items 1 apa default asc 1
Investigators demonstrated that human midbrain organoids showed essential neuronal functional properties as spontaneous electrophysiological activity of different neuronal subtypes, including dopaminergic, GABAergic, glutamatergic and serotonergic neurons.
[Cell and Tissue Research]
6445212 KYFPRAKT items 1 apa default asc 1
Smits, L. M., Magni, S., Kinugawa, K., Grzyb, K., Luginbühl, J., Sabate-Soler, S., Bolognin, S., Shin, J. W., Mori, E., Skupin, A., & Schwamborn, J. C. (2020). Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. Cell and Tissue Research. https://doi.org/10.1007/s00441-020-03249-y Cite
Neural ribbons offer multifunctionality in vitro including co-encapsulation of the injury site ESM modifier chondroitinase ABC, tested in glial scar models, and ability of cervically-patterned spinal cord neural stem cells to differentiate within neural ribbons and project axons for integration with 3D external matrices.
6630899 SUNYGVIN items 1 apa default asc 1
Olmsted, Z. T., Stigliano, C., Badri, A., Zhang, F., Williams, A., Koffas, M. A. G., Xie, Y., Linhardt, R. J., Cibelli, J., Horner, P. J., & Paluh, J. L. (2020). Fabrication of homotypic neural ribbons as a multiplex platform optimized for spinal cord delivery. Scientific Reports, 10(1), 12939. https://doi.org/10.1038/s41598-020-69274-7 Cite
Scientists investigated immunomodulatory potential of human Wharton’s jelly mesenchymal stem cells derived extracellular vesicles on inflammasome activity one week after spinal cord injury in rats.
1254621 CH8SZ5IJ items 1 apa default asc 1
The authors report the directed self-organization of human induced pluripotent stem cells in a collagen hydrogel towards a highly interconnected neuronal network at a macroscale tissue format.
6630899 WMP52IZL items 1 apa default asc 1
Zafeiriou, M.-P., Bao, G., Hudson, J., Halder, R., Blenkle, A., Schreiber, M.-K., Fischer, A., Schild, D., & Zimmermann, W.-H. (2020). Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids. Nature Communications, 11(1), 3791. https://doi.org/10.1038/s41467-020-17521-w Cite
The authors described a robust genetic program that intrinsically attenuated apoptosis competence in neurons.
6606345 IXNUI2B9 items 1 apa default asc 1
The authors suggested that Sp1 was required for p53-mediated transactivation of neuronal pro-apoptotic molecules and that mithramycin might have attenuated neuronal cell death in conditions predominantly involving DNA-damage-induced p53-dependent intrinsic apoptosis.
[Cell Death & Disease]
6606345 B89JT8HV items 1 apa default asc 1
Researchers used channelrhodopsin-2 transfected mouse ESC-derived motor neurons to explore short and long-term programming of neural networks by using optical stimulation implemented during neurogenesis and synaptogenesis.
6630899 3GPC4LVS items 1 apa default asc 1
The authors investigated the therapeutic potential of neural precursor cells derived from human HLA‐homozygous induced pluripotent stem cells following intracerebral transplantation into a rodent model of middle cerebral artery occlusion.
1254621 JNDRA9QI items 1 apa default asc 1
The authors performed cellular, kinematic, physiological, and anatomical analyses, either in vitro or in vivo, to comprehensively evaluate the safety and efficacy associated with subarachnoid transplantation of human umbilical cord mesenchymal stem cells in rats with subacute incomplete spinal cord injury.
[Experimental Cell Research]
1254621 K57MAXHB items 1 apa default asc 1
Investigators determined the ability of the R-GSIK scaffold in supporting the effects of mesenchymal stem cells on motor function activity and inflammatory responses in an experimental traumatic brain injury model.
[Cell and Tissue Research]
1254621 MP4EFWGH items 1 apa default asc 1