neural cells

[npj Aging and Mechanisms of Disease] Scientists used the YAC128 murine model of Huntington’s disease to examine the effects of mutant huntingtin on mitochondrial parameters related to aging in brain and skeletal muscle.

[Scientific Reports] Researchers used machine learning techniques to characterize and predict the developing spontaneous activity in mouse cortical neurons on microelectrode arrays during the first three weeks in vitro.

[Cell Death Discovery] Researchers evaluated the effects of Pgam5 on neurological deficits and neuroinflammation of controlled cortical impact-induced TBI mouse model in vivo and LPS+ ATP-induced microglia model in vitro.

[Proceedings of the National Academy of Sciences of the United States of America] Microglial ramification, motility, and cytokine release are regulated by tonically active THIK-1 K+ channels on the microglial plasma membrane. Researchers examined whether these channels played a role in phagocytosis.

[Neuropsychopharmacology] An understanding of the development and evolution of the PFC provide insight into the pathogenesis and treatment of congenital neuropsychiatric diseases as well as idiopathic developmental disorders that cause intellectual disabilities.

[The Hereditary Neuropathy Foundation] The Hereditary Neuropathy Foundation (HNF), in partnership with Rarebase, is leading the charge in the first-ever research initiative to tackle multiple types of CMT in one project, with a primary goal to test candidate drugs in patient-derived cellular models, specifically; iPSC-derived neurons.