neural cells

[Molecular Cell] ESCs expressing a chimeric CBX7 were impaired in their ability to properly form embryoid bodies and neural progenitor cells and showed reduced activation of lineage-specific genes across differentiation.

[ACS Chemical Neuroscience] The authors discuss the role of PSC-derived neural precursor cells in rat models of MPTP-induced Parkinson’s disease following intranasal injections.

[Journal of Experimental Medicine] The authors interrogated gene expression profiles from glioblastoma stem cells, differentiated glioblastoma cells, and neural stem cells, revealing EYA2 as preferentially expressed by GSCs.

[Science Advances] The authors designed PEGylated lipid nanoparticles loaded with a non-opioid analgesic, bupivacaine, to target neurons within breast cancer tumors and suppress nerve-to-cancer cross-talk.

[Nature Communications] Researchers showed that Acly expression was reduced upon loss of Elongator activity, further connecting Elongator to Atat1 in a pathway regulating α-tubulin acetylation and MT-dependent transport in projection neurons, across species.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists combined glial chemogenetics with genetically encoded calcium indicators expressed in enteric neurons and glia to study network-level activity in the intact myenteric plexus of the proximal colon.