neural cells

[Scientific Reports] Renshaw cells (RCs) are one of the most studied spinal interneurons; however, their roles in motor control remain enigmatic in part due to the lack of experimental models to interfere with RC function, specifically in adults. Scientists leveraged the distinct temporal regulation of Calbindin expression in RCs to create genetic models for timed RC manipulation.

[Scientific Reports] Scientists identified specific modulators of alpha synuclein gene (SNCA) transcription, generated CRISPR/Cas9 modified SNCA-GFP-luciferase genomic fusion- and control cell lines and screened a library of 1649 bioactive compounds, including the FDA approved drugs.

[Cell Death & Disease] Researchers found that YAP was upregulated and activated in astrocytes of spinal cords of encephalomyelitis mice through suppression of the Hippo pathway.

[BMC Biology] Investigators reported the development of a novel human iPSC-derived, inducible neuronal model of Niemann-Pick disease, type C1, and demonstrated the utility of this new cell line in high-throughput drug/chemical screens to identify potential therapeutic agents.

[Nature Communications] Researchers developed and characterized two new organotypic cultures from hamster brainstem and lung tissues that offered a unique opportunity to study the early steps of viral infection and screening antivirals.

[Experimental Neurology] Researchers investigated whether hypoxic postconditioning (HPC) could promote neurogenesis after ischemic stroke, and to investigate the role of neuronal stem cell metabolism in HPC-induced neuroprotection.