neurons

[Cell Death & Disease] By exposing bEnd.3 endothelial cells and primary cortical neurons to oxygen−glucose deprivation (OGD), the impact of extracellular vesicles from OGD-preconditioned microglia on angiogenesis and neuronal apoptosis by the tube formation assay and TUNEL staining was assessed.

[Molecular Neurobiology] Investigators evaluated the effects of human umbilical cord mesenchymal stem cell-conditioned medium in a new in vitro model of neurons differentiated from Dravet syndrome patient-derived iPSCs.

[Cell Death & Disease] Researchers used a model of cerebral contusion and receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase like knockout (MLKL−/−) mice, and found evidence for activation of RIPK3 and MLKL and assembly of a RIPK1-RIPK3-MLKL necrosome complex in pericontusional brain tissue.

[Scientific Reports] Using two clonal gene-corrected isogenic cell lines, investigators identified image-based phenotypes showing impaired neuritic processes. The pathological neurons displayed impaired neuronal activity, reduced mitochondrial respiration, and transcriptional alterations in lipid metabolism.

[Molecular Psychiatry] Scientists review the existing experimental and translational research pinpointing the complex dynamics of oxidative stress mechanisms and their modulation in relation to schizophrenia pathophysiology.

[Scientific Reports] Providing a 3D permissive environment with epothilone B significantly improved motor neuron-like cell differentiation and maturation of human endometrial stem cells (hEnSCs) and was a promising approach to replace lost neurons after spinal cord injury.