neurons

[Cell Death & Disease] Investigators presented the role of the actin-regulating protein cofilin1 in regulating mitochondrial pathways in oxidative neuronal death.

[Science Advances] Gastrointestinal motility disorders occur frequently in patients with ciliopathy, but the underlying genetic link is unclear. Mechanistically, Kif7 inhibited Gli2 in enteric neural crest cells, where Gli2 positively regulated the expression of Ezh2 by inhibiting the miR124-mediated suppression.

[Movement Disorders] Investigators evaluated the difference between controls' and phosphatase and tensin homolog-induced putative kinase 1 (PINK1) patients' derived neurons in their transition from neuroepithelial stem cells to neurons, allowing them to identify potential pathways to target with repurposed compounds.

[npj Aging and Mechanisms of Disease] Scientists used the YAC128 murine model of Huntington’s disease to examine the effects of mutant huntingtin on mitochondrial parameters related to aging in brain and skeletal muscle.

[Scientific Reports] Researchers used machine learning techniques to characterize and predict the developing spontaneous activity in mouse cortical neurons on microelectrode arrays during the first three weeks in vitro.

[Cell Death Discovery] Researchers evaluated the effects of Pgam5 on neurological deficits and neuroinflammation of controlled cortical impact-induced TBI mouse model in vivo and LPS+ ATP-induced microglia model in vitro.