neurons

[Scientific Reports] Scientists identified specific modulators of alpha synuclein gene (SNCA) transcription, generated CRISPR/Cas9 modified SNCA-GFP-luciferase genomic fusion- and control cell lines and screened a library of 1649 bioactive compounds, including the FDA approved drugs.

[Cell Death & Disease] Researchers found that YAP was upregulated and activated in astrocytes of spinal cords of encephalomyelitis mice through suppression of the Hippo pathway.

[BMC Biology] Investigators reported the development of a novel human iPSC-derived, inducible neuronal model of Niemann-Pick disease, type C1, and demonstrated the utility of this new cell line in high-throughput drug/chemical screens to identify potential therapeutic agents.

[Nature Communications] Researchers developed and characterized two new organotypic cultures from hamster brainstem and lung tissues that offered a unique opportunity to study the early steps of viral infection and screening antivirals.

[Cell Reports] Researchers demonstrated that glutamate receptors of the kainate receptor subfamily were expressed in adult-born dentate granule cells and that, through their interaction with GABAergic signaling mechanisms, they altered the functional properties of adult-born cells during a critical period of their development.

[Cell] Using stringent lineage tracing in the mouse brain, investigators showed that the presumed astrocyte-converted neurons were actually endogenous neurons.