neurons

[Trends in Neurosciences] The authors review the development, distribution, neurochemical phenotypes, and possible functions of pericellular baskets. They highlight pericellular baskets formed by projections of certain Pet1/Fev neurons of the serotonergic raphe nuclei.

[Scientific Reports] Scientists used human iPSCs and generated a developmental timeline by differentiating sporadic amyotrophic lateral sclerosis (sALS) iPSCs to neural progenitors and to motor neurons and comparing mitochondrial parameters with familial ALS and control cells at each developmental stage.

[Beneficial Microbes] The authors reported that the intestinal commensal microbe Limosilactobacillus reuteri ATCC PTA 6475 secretes 83.4 mM ethanol. Consistent with the activity of L. reuteri alcohol dehydrogenases, they found that L. reuteri tolerated various levels of ethanol.

[Scientific Reports] Researchers presented human patient induced pluripotent stem cell-derived neurons cultured on densely-spaced spiky silicon nanowire arrays which showed mature electrophysiological characteristics after only 20 days of culturing.

[nan] PathMaker Neurosystems, Inc. announced that it was awarded a Phase I STTR grant from NIH’s National Institute of Neurological Disorders and Stroke. The $371,000 award will enable the completion of key pre-clinical studies evaluating the effect of treatment with PathMaker’s breakthrough technology for motor neuron hyperexcitability suppression in transgenic ALS mice.

[International Journal of Oncology] As the tumor microenvironment is typically acidic due to increased glycolysis and consequently leads to an increased production of lactic acid in tumor cells, the role of acid‑sensing ion channel 1a (ASIC1a), an acid sensor, was explored as a tumor suppressor in gliomagenesis and stemness.