Newly infiltrated inflammatory monocytes become a chief pool of phagocytes and play a key role in the clearance of highly motile apoptotic neutrophils during the resolution phase.
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Scientists investigated whether a bioengineered scaffold device containing hypoxia‐preconditioned, allogeneic human mesenchymal stem cells combined with the beta‐adrenergic antagonist timolol could improve impaired wound healing in diabetic mice.
[Stem Cells Translational Medicine]
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Yang, H., Fierro, F., So, M., Yoon, D. J., Nguyen, A. V., Gallegos, A., Bagood, M. D., Rojo‐Castro, T., Alex, A., Stewart, H., Chigbrow, M., Dasu, M. R., Peavy, T. R., Soulika, A. M., Nolta, J. A., & Isseroff, R. R. (n.d.). Combination product of dermal matrix, human mesenchymal stem cells, and timolol promotes diabetic wound healing in mice. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.19-0380 Cite
Although both caspase-1 and caspase-11 could cleave gasdermin D in macrophages and neutrophils, researchers found that NLRC4-activated caspase-1 triggered pyroptosis in macrophages, but this pathway did not trigger pyroptosis in neutrophils.
Investigators profiled >25,000 differentiating and mature mouse neutrophils using single-cell RNA sequencing to provide a comprehensive transcriptional landscape of neutrophil maturation, function and fate decision in their steady state and during bacterial infection.
Scientists studied the role of extracellular cold-inducible RNA-binding protein, a novel damage-associated-molecular-pattern molecule, in severe acute pancreatitis.
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Linders, J., Madhi, R., Rahman, M., Mörgelin, M., Regner, S., Brenner, M., Wang, P., & Thorlacius, H. (2020). Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis. Laboratory Investigation, 1–13. https://doi.org/10.1038/s41374-020-0469-5 Cite
Cytokine secretion from HCT116 cells and cellular migration were attenuated by inhibiting F. nucleatum host-cell binding and entry using galactose sugars, L-arginine, neutralizing membrane protein antibodies, or fap2 deletion. F. nucleatum also induced the mobilization of immune cells in the tumor microenvironment.
The authors surmise that neutrophils can provide tools to tailor current immunotherapy strategies and pave the way to myeloid cell-centred therapeutic strategies, which would be complementary to current approaches.
[Nature Reviews Cancer]
To examine donor cell survival and host immune reaction, pig bone marrow‐derived mesenchymal stem cells were labeled with CM‐DiI, loaded onto gelatin sponge, and transplanted into 5‐mm mandibular defects of immunocompetent and T cell‐deficient athymic rats.
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The authors uncovered a fundamental role of commensal skin microbiota and showed that it was mediated by the recruitment and the activation of type I interferon (IFN)-producing plasmacytoid DC.
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Scientists outline pathways for the major cell death programmes and their potential roles in chronic inflammation. They also discuss current and developing therapies that target the cell death machinery.
[Nature Reviews Rheumatology]
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Researchers reviewed pre‐diagnosis clinical data of 420 patients with pathologically confirmed myelodysplastic syndromes presenting with anemia.
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Investigators performed RNA sequencing on circulating neutrophils from healthy adult females and males. Female neutrophils displayed significant up-regulation of type I IFN-stimulated genes.
[Proceedings of the National Academy of Sciences of the United States of America]
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