NF-κB

[Acta Pharmacologica Sinica] Scientists investigated whether sapidolide A exerted protective effects on macrophages, thus alleviating the secondary hepatocyte damage in an acetaminophen-induced liver injury.

[Journal of Enzyme inhibition and Medicinal Chemistry] The potential synergistic anticancer effect and the underlying mechanisms of roburic acid in combination with docetaxel on prostate cancer were investigated.

[International Journal of Stem Cells] Researchers reported the effects of diesel exhaust particles exposure on the properties of human Wharton’s jelly-derived mesenchymal stem cells, including stemness, regeneration, and immunomodulation.

[Oncogene] FGD3, which is involved in regulating the actin cytoskeleton and cell shape, has been reported to inhibit cancer cell migration and predict a favorable prognosis in multiple types of cancer. Researchers conducted a systematic investigation of the cancer-related role of FGD3 in pancreatic cancer.

[Journal of Experimental Medicine] The authors found that the STING S365A mutation, which abrogated IRF3 binding and type I interferon induction, rescued the embryonic lethality of DNase II−/− mice.

[Scientific Reports] Researchers established inducible P18/hESC lines and monitored the effects of P18 overexpression on hematopoietic differentiation and found evidence that P18 promoted hematopoiesis, a rare property among cyclin-dependent kinase inhibitors.