obesity

[Experimental and Molecular Medicine] The authors review the biochemical steps of hepatic lipid metabolism, dysregulated lipid metabolism in obesity and nonalcoholic fatty liver disease (NAFLD), and the roles of IκB kinase complexes and TANK-binding kinase 1 in obesity and NAFLD.

[Nature Communications] Scientists applied methods to greatly expand human adipocyte progenitors from small samples of human subcutaneous adipose tissue and then disrupt the thermogenic suppressor gene NRIP1 by CRISPR.

[Stem Cell Reviews and Reports] Researchers suggested that inter-organ communication on the level of stem progenitor cells-HSTCs and ASCs could represents a key mechanism involved in controlling glucose tolerance as well as insulin sensitivity.

[Cell Metabolism] Using single-cell transcriptomics, the authors identified a small, critically important, but previously unexamined cell population, p21Cip1 highly expressing (p21high) cells, which accumulated in adipose tissue with obesity.

[Science Signaling] Researchers found that primary human adipocytes shed extracellular vesicles, specifically exosomes, that induced the expression of genes associated with epithelial-to-mesenchymal transition and cancer stem–like cell traits in cocultured breast cancer cell lines.

[Diabetes] Scientists assessed the roles of GRP75, other than as a component, in insulin action in both in vitro and in vivo models with insulin resistance.