obesity

[Bioengineered] The authors investigated the function and mechanism of demethyltransferase fat mass and obesity-associated protein (FTO) in prostate cancer (PCa). FTO regulated the proliferation, migration and invasion of PCa via regulating the expression level of MC4R.

[Scientific Reports] Investigators found that elastolysis of elastic fibers and collagen accumulation contributed to vascular stiffening and arterial hypertension. Therefore, apelin expression could be a major element to preserve vascular homeostasis.

[iScience] Inhibition of matrix metalloprotease 2 (MMP2) restricted functional transfer of hepatic miRNAs across the hepatic and non-hepatic cell boundaries and by targeting MMP2, scientists could reduce the innate immune response in mammalian liver by preventing intra-tissue miR-122 transfer.

[European Journal of Clinical Investigation] Scientists review the updates in epidemiology and molecular mechanism of high-salt diet (HSD)-induced non-alcoholic fatty liver disease and provide a novel insight into the role of HSD in the regulation of lipid metabolism.

[Nature Metabolism] Scientists showed that the Hedgehog signaling pathway induced a previously undefined long non-coding RNA, which controlled hepatic lipid metabolism.

[Translational Research] Researchers demonstrated a direct effect of cholecystokinin to reduce cytokine-mediated apoptosis in a β-cell line and in isolated mouse islets in a receptor-dependent manner.