Inhibition of Extracellular Vesicle-Associated MMP2 Abrogates Intercellular Hepatic miR-122 Transfer to Liver Macrophages and Curtails Inflammation

Inhibition of matrix metalloprotease 2 (MMP2) restricted functional transfer of hepatic miRNAs across the hepatic and non-hepatic cell boundaries and by targeting MMP2, scientists could reduce the innate immune response in mammalian liver by preventing intra-tissue miR-122 transfer.