obesity

[Trends in Endocrinology and Metabolism] The authors discuss adiposopathy with a focus on adiponiche dysfunction, and underline the mechanisms that control adipose tissue expansion and energy balance.

[Pharmacological Research] The mechanisms of obesity and diabetes and the crosstalk between these diseases are still ambiguous. The authors clarified and explained the role of VGF peptides in the brain, pancreas, and adipose tissue in the development of obesity.

[Liver International] Scientists summarize cross-sectional human studies using liver biopsy/lipidomics and proton magnetic resonance spectroscopy to characterize hepatic lipid composition in people with obesity and related metabolic disease.

[POXEL SA] POXEL SA announced the completion of enrollment in DESTINY-1, a dose-ranging Phase II trial evaluating PXL065 for the treatment of non-alcoholic steatohepatitis (NASH).

[Molecular Therapy-Nucleic Acids] Scientists experimentally verified one such micropeptide encoded by a β cell- and neural cell-enriched lncRNA TCL1 upstream neural differentiation-associated RNA. They provided the first evidence that lncRNA-encoded micropeptides played a critical role in pancreatic β cell functions and provided a foundation for future comprehensive analyses of micropeptide function and pathophysiological impact on diabetes.

[CohBar, Inc.] CohBar, Inc. announced the United States Patent and Trademark Office has granted a patent, US No. 11,111,271, covering CohBar’s lead candidate CB4211 and related compositions, as well as methods of treatment, including methods of treating NASH.