obesity

[Cellular & Molecular Immunology] Investigators describe the pro-tumorigenic roles of lipid uptake, metabolism and synthesis and detail the therapeutic potential of targeting lipid metabolism in cancer.

[Cell Chemical Biology] Scientists revealed a functional duality of the Irs2 gene locus, where reciprocal changes of Irs2 and ASIrs2 in obesity caused insulin resistance and steatosis.

[Reproductive Toxicology] Scientists revealed that the levels of 5-methylcytosine (5mC), were significantly increased coupled with decreased activity of Ten-Eleven Translocation (TETs) enzymes that principally function by oxidizing 5mC in the obese placenta, consistent with hypoxia-induced genome-wide DNA hypermethylation observed in varied types of cells and tissues.

[Peptides] Investigators describe mechanisms involved in insulin secretion as well as metabolic and mitogenic actions on its target tissues.

[Journal of Parenteral and Enteral Nutrition] Researchers investigated treatment with calcitriol on mesenteric lymph node CD4+ T cell polarization and intestinal injury in obese mice with sepsis.

[SynDevRx, Inc. (Businesswire, Inc.)] SynDevRx, Inc. announced a research collaboration with Australia’s Queensland University of Technology. The collaboration with Professor Colleen Nelson, PhD, and her team will study the role of methionine aminopeptidase 2 inhibition in tumor growth in castration resistant and other treatment resistant forms of prostate cancer.