organoids

[World Journal of Surgical Oncology] The development, applications, strengths, and challenges of patient-derived models in cancer research are characterized.

[Nature Communications] Using patient-derived ectocervical organoids, scientists systematically modeled individual and coinfection dynamics of human papillomavirus (HPV)16 E6E7 and Chlamydia, associated with carcinogenesis.

[Cellular and Molecular Life Sciences] The in vitro and in vivo results indicated that CD133+ stem cell-like cells are the main subpopulation and PARP1 was the central gene mediating oxaliplatin resistance in gastric cancer.

[Bioorganic Chemistry] All isolated analogues were screened for the cytotoxicity against intrahepatic cholangiocarcinoma cell lines of HuCCT1 and RBE through tumor colony formation and CCK-8 survival analysis.

[Oncotarget] Scientists investigated the impact of shortened telomeres in a mouse model for Barrett esophagus. The L2-IL1B mouse model was characterized by IL-1β-mediated inflammation, which led to a Barrett-like metaplasia in the transition zone between the squamous forestomach and glandular cardia/stomach.

[Genome Medicine] DevKidCC was used to directly compare between distinct kidney organoid protocols, identifying differences in relative proportions of cell types at all hierarchical levels of the model.