Telomere Shortening Accelerates Tumor Initiation in the L2-IL1B Mouse Model of Barrett Esophagus and Emerges as a Possible Biomarker

Scientists investigated the impact of shortened telomeres in a mouse model for Barrett esophagus. The L2-IL1B mouse model was characterized by IL-1β-mediated inflammation, which led to a Barrett-like metaplasia in the transition zone between the squamous forestomach and glandular cardia/stomach.