organoids

[Cancer Communications] Advances in 3D organoid culture technology have led to the development of novel physiological systems that model the tissues of origin more precisely than traditional culture methods.

[JCI Insight] Researchers aimed to better understand the tumor epithelium-targeted mechanisms of bacterial cancer therapy by using autochthonous mouse models of intestinal cancer and tumor organoid cultures to assess the effectiveness and consequences of oral treatment with aromatase A-deficient STm.

[EMBO Journal] Investigators showed that both pluripotent stem cell-derived human intestinal organoids engrafted into mice and patient-derived human intestinal enteroids possessed circadian rhythms and demonstrated circadian phase-dependent necrotic cell death responses to Clostridium difficile toxin B.

[Translational Oncology] Scientists created organoid microarrays and visualized bulk and spatial differences in cell proliferation using immunohistochemistry staining, and cell cycle analysis by flow cytometry paired with 3D regional labeling.

[American Journal of Psychiatry] An in vitro model of fetal human brain development, induced human iPSC–derived cerebral organoids, were used to test whether cerebral organoids were suitable for studying the impact of prenatal glucocorticoid exposure on the developing brain.

[eLife] The authors presented a method that combined cryo-correlative light microscopy and electron tomography with human cerebral organoid technology to visualize growing axon tracts.