organoids

[XtalPi] Signet Therapeutics and XtalPi Inc. announced the expansion of their AI drug discovery collaboration to include a new first-in-class program against a novel cancer target identified by Signet. The follow-on project will continue to combine XtalPi’s AI drug discovery platform with Signet’s unique novel organoid disease models to generate pipeline candidates and advance them toward clinical trials.

[Molecular Psychiatry] Investigators discuss dynamic and non-overlapping spatiotemporal protein-level programs and their potentially essential role for unraveling critical secreted paracrine signals or neurodevelopmental proteins requiring post-translational modification for biological activity.

[EMBO Reports] Researchers optimized differentiation of airway organoids (AOs) towards ciliated cells. After differentiation of the AOs towards ciliated cells, these could be studied for weeks.

[Scientific Reports] Scientists reported that human iPSC-derived retinal organoids release exosomes and microvesicles with small noncoding RNA cargo.

[Biofabrication] Investigators presented a method to model the peristalsis for human colon tumor organoids on a microfluidic chip.

[Trends in Molecular Medicine] Investigators provide a retrospective account of organoid methodologies and outline new opportunities for optimizing these methods to further explore emerging concepts in lung biology.