organoids

[Movement Disorders] Investigators evaluated the difference between controls' and phosphatase and tensin homolog-induced putative kinase 1 (PINK1) patients' derived neurons in their transition from neuroepithelial stem cells to neurons, allowing them to identify potential pathways to target with repurposed compounds.

[Amino Acids] Experiments in piglet jejunum organoids revealed that the mix of amino acids and polyphenols upregulated the gene expression of epithelial differentiation markers while it reduced the gene expression of proliferation and innate immunity markers.

[Cancer Discovery] The authors observed increased plasma cell proportions in diffuse-type tumors associated with epithelial-resident KLF2, and stage-wise accrual of cancer-associated fibroblast sub-populations marked by high INHBA and FAP co-expression.

[BMC Biotechnology] Scientists investigated the effects of early geometric confinements on transcriptomic changes during human cerebral organoids differentiation.

[ACS Nano] The authors investigated the profitable effect of carbon nanotubes (CNTs) with a different graphene layer and surface modification on the 3D model of intestinal organoids and demonstrated that CNTs promoted the development of intestinal organoids over time.

[Clinical Cancer Research] Four patient-derived xenografts, two patient-derived organoi and two xenografts of human glioma cell lines were used to further investigate the therapeutic efficacy of 6-thio-2'-deoxyguanosine.