organoids

[Pharmacology & Therapeutics] Owing to the recent developments in mesenchymal stem cells and induced pluripotent stem cells, combined with emerging technologies including graphene, nano-biomaterials, and gene editing, precision medicine and individualized clinical treatment may be realized in the near future.

[Experimental Cell Research] Scientists discuss the patient-derived organoids as a native tumor microenvironment mimicking model in personalized cancer therapy.

[Cell Death & Disease] Scientists reported that metformin treatment increased the sensitivity of hepatocarcinoma cells to methotrexate by suppressing the expression of the one-carbon metabolism enzyme dihydrofolate reductase.

[eLife] Investigators reported serum-free conditions that allowed for growth and differentiation of mouse distal lung epithelial progenitors.

[Molecular Cancer] Scientists evaluate the advances in 3D culture and patient derived organoid (PDO) use to model clonal heterogeneity and screen for effective targeted therapies, with a focus on the technological advances in generating PDOs.

[Cell Death & Disease] Scientists investigated the function of argininosuccinate synthetase (ASS1) in the gut epithelium during tissue regeneration and tumorigenesis, using intestinal epithelial conditional Ass1 knockout mice and organoids, and tissue specimens from colorectal cancer patients.