organoids

[Journal of Cellular and Molecular Medicine] Investigators discuss about various organoid culture strategies for modelling the tumour immune microenvironment, their applications and advantages in cancer research.

[Scientific American] Bone stands apart because its different cell types exist within an extracellular matrix, a continuously remodeled network of collagen and minerals. Previous organoid attempts have failed to capture how human bone cells form in parallel with this matrix and interact with it.

[Cell Proliferation] The authors developed a rapid and immune sufficient mouse model for liver metastasis of prostate cancer via orthotopic injection of organoids from PbCre+; rb1f/f;p53f/f mice.

[Nature Communications] By ATAC-seq analyses of EpCAM+ pancreatic ductal adenocarcinoma malignant epithelial cells sorted from 54 freshly resected human tumors, we show here the discovery of a signature of 1092 chromatin loci displaying differential accessibility between patients with disease free survival (DFS) 1 year.

[Scientific Reports] Patient-derived xenograft models were established from 276 pancreato-duodenal and biliary cancer resections. Pancreatic ductal adenocarcinoma (PDAC), had a P0 engraftment rate of 62%.

[Acta Biomaterialia] The authors discuss the status, applications, challenges and perspectives of intestinal organoid systems emphasising on hydrogels and their properties suitable for intestinal organoid culture.