osteoblasts

[Molecular Medicine Reports] The latest research findings on the development and differentiation, culture techniques and labeling and tracing of umbilical cord blood stem cells are reviewed.

[Biochemical and Biophysical Research Communications] MSCs were characterized by flow cytometry with more than 90% CD44 and 75% Sca-1 labeling. Mineralization was validated with paracellular alkaline phosphatase activity, collagen birefringence, and mineral deposition confirming MSCs identity.

[Bone Research] Scientists observed increased activation of pERK1/2 in osteolytic breast cancer cells and osteoblasts in human pathological specimens with aggressive osteolytic breast cancer metastases.

[Leukemia] Scientists examined the effects of plasma from myeloma patients at diagnosis and in complete remission and from healthy donors on the osteoblastic differentiation of healthy donor-derived adipose-dervied MSCs.

[Chemico-Biological interactions] The osteogenic role of prepared complex under in vivo was studied by an in-house zebrafish scale model followed by osteoblast differentiation markers expression profiling and Ca:P level measurement by ICP-MS.

[Cell Stem Cell] The authors demonstrated that osteoblastic cells in the bone marrow niche elaborated extracellular vesicles (EV) that were taken up by hematopoietic progenitor cells in vivo, and that upregulating EV transfer improved hematopoietic recovery from genotoxic injury and survival from fungal sepsis.