osteogenic differentiation

[Biomacromolecules] The authors describe self-assembling tetrapeptide scaffolds for the growth and osteogenic differentiation of human MSCs. The rationally designed peptides are synthetic amphiphilic self-assembling peptides composed of four amino acids that are nontoxic.

[Aging] Researchers found osteogenic cells from aged rats all exhibited senescence changes, with the most pronounced senescence changes in osteocytes. Meanwhile, the proliferative capacity and functional activity of osteogenic cells from aged rats were suppressed.

[JCI Insight] Investigators created a high throughput screening and identified SB216763, an inhibitor of glycogen synthase kinase 3, as an inducer of osteoblastic-endothelial transition.

[Journal of Immunology and Regenerative Medicine] Researchers demonstrated that macrophages adopt distinct phenotypes when exposed to articular cartilage, ligament and growth plate derived extracellular matrix scaffolds.

[Bioprocess and Biosystems Engineering] Mouse clonal MSCs were cultured on a Cytodex 3 microcarrier in a spinner flask for a suspension culture under hypoxia condition to increase mass productivity.

[NPG Asia Materials] A novel biofunctional live tissue-engineered bone-like graft was designed and constructed using a fibrin scaffold loaded with TG2 gene-modified ectomesenchymal stem cells (TG2-EMSCs) derived from nasal respiratory mucosa for bone defect repair.