osteogenic differentiation

[Cell Death & Disease] Researchers investigated molecular mechanisms underlying circular RNA AFF4-regulated Bone marrow-derived-MSCs osteogenesis.

[Proceedings of the National Academy of Sciences of the United States of America] Parathyroid hormone (PTH) and sclerostin inhibitor (SOSTi) are bone anabolic agents that are administered to patients with osteoporosis. Scientists tested whether osteolectin mediates the effects of PTH or SOSTi on bone formation.

[Tissue Engineering and Regenerative Medicine] IL1β priming Tonsil-derived MSCs had an enhanced osteogenic differentiation and secreted factors that regulate both osteoclastogenesis and osteoblastogenesis.

[Scientific Reports] To elucidate cell type-specific differences in the osteogenic differentiation potential and replicative senescence, researchers analyzed the impact of BMP and TGF-β signaling in adipose-derived stromal cells, fibroblasts, and dental pulp stromal cells.

[Cell Death & Disease] Researchers showed that conditional knockout of the demethylase Alkbh5 in bone marrow MSCs strengthened bone mass in mice.

[Scientific Reports] Researchers investigated whether pro-autophagic γ-aminobutyric acid receptor-associated protein (GABARAP) promoted bone MSCs proliferation and osteogenic differentiation by modulating autophagy in the presence or absence of interleukin-1 beta (IL-1β) in vitro.