Osteogenic Differentiation of Human Mesenchymal Stromal Cells and Fibroblasts Differs Depending on Tissue Origin and Replicative Senescence

To elucidate cell type-specific differences in the osteogenic differentiation potential and replicative senescence, researchers analyzed the impact of BMP and TGF-β signaling in adipose-derived stromal cells, fibroblasts, and dental pulp stromal cells.