Tonicity-responsive enhancer binding protein (TonEBP) was required for the tumorigenesis and self-renewal of liver CSCs. Cisplatin induced the recruitment of the ERCC1/XPF dimer to the chromatin in a TonEBP-dependent manner leading to DNA repair and cisplatin resistance.
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Lee, J. H., Suh, J. H., Kang, H. J., Choi, S. Y., Jung, S. W., Lee-Kwon, W., Park, S.-A., Kim, H., Ye, B. J., Yoo, E. J., Jeong, G. W., Park, N. H., & Kwon, H. M. (2020). Tonicity-responsive enhancer-binding protein promotes stemness of liver cancer and cisplatin resistance. EBioMedicine, 58. https://doi.org/10.1016/j.ebiom.2020.102926 Cite
Researchers observed the expression of selenoprotein P in livers from patients with hepatocellular carcinoma (HCC) and explored its effect on HCC cells.
Neohesperidin (NHP) elevated hepatic mitochondrial biogenesis and fatty acid oxidation by increasing PGC-1α expression. The activation of AMP-activated protein kinase was involved in NHP induced PGC-1α expression.
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Scientists showed that deletion of endothelial epsin proteins reduced inflammation and attenuated atherosclerosis using both cell culture and mouse models of atherosclerosis.
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Dong, Y., Lee, Y., Cui, K., He, M., Wang, B., Bhattacharjee, S., Zhu, B., Yago, T., Zhang, K., Deng, L., Ouyang, K., Wen, A., Cowan, D. B., Song, K., Yu, L., Brophy, M. L., Liu, X., Wylie-Sears, J., Wu, H., … Chen, H. (2020). Epsin-mediated degradation of IP3R1 fuels atherosclerosis. Nature Communications, 11(1), 3984. https://doi.org/10.1038/s41467-020-17848-4 Cite
Investigators showed that an 18 hour exposure of human pulmonary artery endothelial cells to the different nanoparticles modestly affects cellular metabolic activity.
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Cell culture experiments were performed in human dermal microvascular endothelial cells and included mRNA and protein analysis, and cell migration and proliferation assays. Ex vivo skin organoid culture was used to evaluate the effect of OSM on perivascular fibrosis.
[Arthritis Research & Therapy]
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Marden, G., Wan, Q., Wilks, J., Nevin, K., Feeney, M., Wisniacki, N., Trojanowski, M., Bujor, A., Stawski, L., & Trojanowska, M. (2020). The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis. Arthritis Research & Therapy, 22(1), 179. https://doi.org/10.1186/s13075-020-02266-0 Cite
Iron sucrose-labeled adipose-derived mesenchymal stem cells were tracked using T2-and T2∗-weighted sequences by 1.5 and 3 T MRI in an in vitro model.
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Scientists present SALSA (ScAffoLd SimulAtor), a general purpose computational tool that can simulate the behavior of a population of cells cultured in a 3D scaffold.
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Researchers showed for the first time that LCN2 mRNA and protein expression were strongly inducible by TNF-α in the highly metastatic human PCa cell line PC-3.
The authors examined the potential of natural AKR1C3 inhibitors in various prostate cancer cell lines and a three-dimensional co-culture spheroid model consisting of cancer cells and cancer-associated fibroblasts mimicking enzalutamide resistant prostate cancer.
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Kafka, M., Mayr, F., Temml, V., Möller, G., Adamski, J., Höfer, J., Schwaiger, S., Heidegger, I., Matuszczak, B., Schuster, D., Klocker, H., Bektic, J., Stuppner, H., & Eder, I. E. (2020). Dual Inhibitory Action of a Novel AKR1C3 Inhibitor on Both Full-Length AR and the Variant AR-V7 in Enzalutamide Resistant Metastatic Castration Resistant Prostate Cancer. Cancers, 12(8), 2092. https://doi.org/10.3390/cancers12082092 Cite
Investigators evaluated the effects of human bone marrow (hBM)-conditioned medium derived from different stages of hBM MSC culture on the osteogenic capacity of perivascular tissue of the human umbilical cord.
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Collagen VI is a ubiquitous heterotrimeric protein of the ECM that plays an essential role in the proper maintenance of skeletal muscle. Scientists investigated structure-function relationships of N2 domain mutations to shed light on their possible myopathy mechanisms.
[Journal of Biological Chemistry]
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