p21

[Cell Cycle] Knockout of killin in human colorectal cells led to a dramatic decrease in p53-mediated G1 arrest upon DNA damage.

[Biochemistry and Cell Biology] Wistar-Kyoto rats and spontaneously hypertensive rats were used to detect the expression of Angptl2. Angiotensin II stimulated vascular smooth muscle cells to mimic hypertension in vitro.

[Cell Metabolism] Using single-cell transcriptomics, the authors identified a small, critically important, but previously unexamined cell population, p21Cip1 highly expressing (p21high) cells, which accumulated in adipose tissue with obesity.

[Cardiovascular Toxicology] Researchers investigated the protective effects of Metoprolol against arginine vasopressin-induced cellular senescence in cultured cardiomyocytes.

[Cancer Research] To clarify the role of ERK5 in melanoma growth, scientists performed transcriptomic analyses following ERK5 knockdown in melanoma cells expressing BRAFV600E and found that cellular senescence was among the most affected processes.

[Journal of Biomedical Science] The role of Receptor tyrosine kinase-like orphan receptor 2 (ROR2) in tumor growth was assessed in xenotransplantation experiments followed by immunohistochemistry analysis of the tumors.